Figure 3: Level of LINE-1 hypomethylation of gastric epithelial dysplasia according to H. pylori state and genetic instability. (a) Irrespective of H. pylori infection, there were no differences of LINE-1 methylation level between LOH-L and LOH-H. (b) In dysplasia with H. pylori infection, LINE-1 methylation level of MSI is significantly reduced than that of MSS. Box plots illustrate median values, 25th and 75th percentiles, and outliers on a linear scale. The unpaired t test was applied for nonparametric statistical analysis, and *was considered statistically significant ( ).