Does Cisapride, as a 5HT₄ Receptor Agonist, Aggravate the Severity of TNBS-Induced Colitis in Rat?

Figure 1

Changes in diarrheal status before (day 0) and during 6 days of treatment after induction of colitis (TNBS, 50 mg/kg) in rats. Values are means ± SEM (𝑛=6). ^∗∗𝑃<0.01 and ^∗𝑃<0.05 compared with TNBS-control group, i.p; ^##𝑃<0.01 and ^#𝑃<0.05 compared with TNBS-control group, p.o TNBS, 2, 4, 6-trinitrobenzenesulfonic acid. Stool consistency was daily checked in rats (1) formed stools, (2) loosed stools, and (3) diarrhea.