Does Cisapride, as a 5HT₄ Receptor Agonist, Aggravate the Severity of TNBS-Induced Colitis in Rat?

Table 1

Scoring criteria for assessment of macroscopic rat colonic injuries.

Adhesions	0 No adhesions
	1 Difficult dissection
	2 Visible adhesions
	3 “Wrapped” intestine
Obstruction	0 No obstruction
	1 Need for gentle manual cleaning
	2 Fecal impaction
Thickening	0 Similar to uninflamed intestine
	1 Thicker than normal (~1-2 mm)
	2 Much thicker than normal (>2 mm)
Hyperemia	0 Similar to uninflamed intestine
	1 Mild and generalized or intense but localized hyperemia
	2 Intense and localized hyperemia
	3 Frank hemorrhage
Necrosis	0 No signs of necrosis
	1 Small areas of necrosis
	2 Patchy necrosis
	3 Focal necrosis <0.8 cm
	4 Focal necrosis >0.8 cm
	5 Extended necrotic lesion