Current psychotropic drugs used for treatment of irritable bowel syndrome.
|Classes of drugs||Mechanism of action||Therapeutic issues|
|Antidepressants (SSRIs, TCADs, SNRIs)||Neurotransmitters reuptake inhibitors||Reduction of abdominal pain; limited data about safety and tolerability|
|Benzodiazepines||Enhancement of GABA inhibitory effect||Limited use; risk of tolerance and rebound withdrawal; lack of reliable antidepressant efficacy|
|Atypical Antipsychotics (Quetiapine)||Receptorial antagonism with dopaminergic (D2) and serotoninergic (5-HT2) receptors||Possible use only in patients with severe psychiatric comorbidities; lacking data and evidence about efficacy and safety in irritable bowel syndrome|
|SSRIs: selective serotonin reuptake inhibitors. TCADs: trycyclic antidepresants. SNRIs: serotonin norepinephrine reuptake inhibitors. 5-HT: 5-hydroxytriptamine.|