Gastroenterology Research and Practice / 2012 / Article / Tab 1

Review Article

Psychopharmacological Treatment and Psychological Interventions in Irritable Bowel Syndrome

Table 1

Current psychotropic drugs used for treatment of irritable bowel syndrome.

Classes of drugsMechanism of actionTherapeutic issues

Antidepressants (SSRIs, TCADs, SNRIs)Neurotransmitters reuptake inhibitorsReduction of abdominal pain; limited data about safety and tolerability
BenzodiazepinesEnhancement of GABA inhibitory effectLimited use; risk of tolerance and rebound withdrawal; lack of reliable antidepressant efficacy
Atypical Antipsychotics (Quetiapine)Receptorial antagonism with dopaminergic (D2) and serotoninergic (5-HT2) receptorsPossible use only in patients with severe psychiatric comorbidities; lacking data and evidence about efficacy and safety in irritable bowel syndrome

SSRIs: selective serotonin reuptake inhibitors. TCADs: trycyclic antidepresants. SNRIs: serotonin norepinephrine reuptake inhibitors. 5-HT: 5-hydroxytriptamine.

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