Review Article
Psychopharmacological Treatment and Psychological Interventions in Irritable Bowel Syndrome
Table 2
Novel psychotropic agents used for the treatment of irritable bowel syndrome.
| Classes of drugs | Mechanism of action | Therapeutic issues |
| Corticotrophin releasing factor antagonists | Modulation of corticoid system | Limited use, under investigation | Opioidergic agents | Modulation of visceral nociception | Limited central side effects, good efficacy | Cholecystokinin receptor antagonists | Modulation of cholecystokinin pathways | Limited use, under investigation | Somatostatin analogues | Inhibition of rectal sensitivity | Limited use and efficacy, under investigation | Beta-3 adrenergic agonists | Modulation of beta-3 adrenergic system | Limited efficacy in bowel symptoms | N-methyl-D-aspartate antagonists | Central and peripheral analgesics | Limited efficacy, restricted on abdominal pain |
|
|