Gastroenterology Research and Practice / 2012 / Article / Tab 2

Review Article

Psychopharmacological Treatment and Psychological Interventions in Irritable Bowel Syndrome

Table 2

Novel psychotropic agents used for the treatment of irritable bowel syndrome.

Classes of drugsMechanism of actionTherapeutic issues

Corticotrophin releasing factor antagonistsModulation of corticoid systemLimited use, under investigation
Opioidergic agentsModulation of visceral nociceptionLimited central side effects, good efficacy
Cholecystokinin receptor antagonistsModulation of cholecystokinin pathwaysLimited use, under investigation
Somatostatin analoguesInhibition of rectal sensitivityLimited use and efficacy, under investigation
Beta-3 adrenergic agonistsModulation of beta-3 adrenergic systemLimited efficacy in bowel symptoms
N-methyl-D-aspartate antagonistsCentral and peripheral analgesicsLimited efficacy, restricted on abdominal pain

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