Novel psychotropic agents used for the treatment of irritable bowel syndrome.
|Classes of drugs||Mechanism of action||Therapeutic issues|
|Corticotrophin releasing factor antagonists||Modulation of corticoid system||Limited use, under investigation|
|Opioidergic agents||Modulation of visceral nociception||Limited central side effects, good efficacy|
|Cholecystokinin receptor antagonists||Modulation of cholecystokinin pathways||Limited use, under investigation|
|Somatostatin analogues||Inhibition of rectal sensitivity||Limited use and efficacy, under investigation|
|Beta-3 adrenergic agonists||Modulation of beta-3 adrenergic system||Limited efficacy in bowel symptoms|
|N-methyl-D-aspartate antagonists||Central and peripheral analgesics||Limited efficacy, restricted on abdominal pain|