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Gastroenterology Research and Practice
Volume 2012 (2012), Article ID 516140, 7 pages
Clinical Study

Health-Related Quality of Life in Chinese Patients with Chronic Liver Disease

Digestive Department, Beijing Chao-Yang Hospital, Capital Medical University, Chao Yang District, Beijing 100020, China

Received 14 January 2012; Revised 9 April 2012; Accepted 11 April 2012

Academic Editor: Edoardo G. Giannini

Copyright © 2012 Ru Gao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aim. To investigate the factors contributing to health-related quality of life (HRQOL) in Chinese patients with chronic liver disease (CLD). Methods. HRQOL was measured with SF-36v2 Chinese version. Demographic and clinical data were collected, and patients with liver cirrhosis were divided into Child’s Class A, B, and C according to Child-Turcotte-Pugh scoring system. Results. A total of 392 Chinese patients with CLD and 91 healthy controls were enrolled. HRQOL in patients with CLD was lower than that in healthy controls. Score of PCS in healthy controls was 54.6±5.5 and in CLD was 47.8±8.8 (P=0.000). Score of MCS in healthy controls was 56.4±8.1 and in CLD was 51.7±7.4 (P=0.000). Increasing severity of CLD from no cirrhosis to advanced cirrhosis was associated with a decrease on all domains of the SF-36 (P<0.05). Stepwise linear regression analysis showed that severity of disease, age, present ascites, present varices, and prothrombin time had significant effect on physical health area. Severity of disease, female, present varices, total bilirubin, prothrombin time, and hemoglobin had significant effect on mental health area. Conclusions. Patients with CLD had impaired HRQOL. Increasing severity of CLD was associated with a decrease on HRQOL. Old age, female gender, advanced stage of CLD, present ascites, hyperbilirubinemia, and prolonging prothrombin time were important factors reducing HRQOL.