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Gastroenterology Research and Practice
Volume 2012, Article ID 529782, 6 pages
Clinical Study

Usefulness of Background Coloration in Detection of Esophago-Pharyngeal Lesions Using NBI Magnification

1Digestive Disease Center, Showa University Northern Yokohama Hospital, 35-1, Chigasaki-Chuo, Tsuzuki, Yokohama 224-8503, Japan
2Department of Gastroenterology and Hepatology, Nagasaki University, 1-7-1, Sakamoto, Nagasaki, Japan

Received 15 May 2012; Accepted 7 July 2012

Academic Editor: Michael Bouvet

Copyright © 2012 Hitomi Minami et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background and Aim. We evaluated the usefulness of background coloration (BC), a color change in the area between intrapapillary capillary loops (IPCLs) in the early esophago-pharyngeal lesions using NBI with magnificaiton. Methods. Between April 2004 and March 2010, a total of 294 esophago-pharyngeal lesions were examined using NBI with magnification, and the presence of BC and IPCL patterns were assessed. Using BC, discrimination of squamous cell carcinoma (SCC) or high-grade neoplasia (HGN) from low-grade neoplasia (LGN) or nonatypia was conducted. Results. Among 294 lesions, 209 lesions (71.1%) were positive for BC, while 85 (28.9%) were negative. In the BC-positive group, 187 lesions (89.5%) were diagnosed as SCC/HGN. And 68 lesions (80.0%) in the BC-negative group were diagnosed as LGN/nonatypia. Overall accuracy of BC to discriminate SCC/HGN from LGN/nonatypia was 87.3%. The sensitivity and specificity were 91.9%, 76.7%. BC could discriminate SCC/HGN from LGN/nonatypia accurately ( ). Among 68 lesions classified into the IPCL type IV, the BC-positive group ( ) included 21 SCC/HGN lesions, while there were 36 LGN/nonatypia lesions in the 42 BC-negative lesions. Conclusions. BC is a useful finding in differentiating SCC/HGN from LGN/nonatypia lesions in the esophagus especially when it is combined with IPCL pattern classification.