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Gastroenterology Research and Practice
Volume 2012, Article ID 537170, 5 pages
http://dx.doi.org/10.1155/2012/537170
Review Article

Endomicroscopy and Cancer: A New Approach to the Visualization of Neoangiogenesis

1Department of Gastroenterology, National Cancer Institute, IRCCS, Via F. Gallini 2, 33081 Aviano, Italy
2Department of Experimental Oncology, National Cancer Institute, IRCCS, Via F. Gallini 2, 33081 Aviano, Italy
3Department of Pathology, National Cancer Institute, IRCCS, Via F. Gallini 2, 33081 Aviano, Italy
4Department of Clinical and Experimental Pharmacology, National Cancer Institute, IRCCS, Via F. Gallini 2, 33081 Aviano, Italy
5National Cancer Institute, IRCCS, Via F. Gallini 2, 33081 Aviano, Italy

Received 6 September 2011; Accepted 4 October 2011

Academic Editor: Giovanni D. de Palma

Copyright © 2012 Renato Cannizzaro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Probe-based Confocal Laser Endomicroscopy (pCLE) is a novel imaging technique for gastrointestinal endoscopy providing in vivo microscopy at subcellular resolution. It offers the possibility to analyze neoangiogenesis and vessel density in vivo. Angiogenetic switch is essential in cancer progression. Aim of the paper was to review the use of this imaging tool to analyze colorectal and gastric cancers vascularization in vivo. The aim is to provide the possibility of combining diagnostic evidences with vascularization and molecular profile to evaluate the efficacy of an antiangiogenic treatment in association with conventional therapy. pCLE can be considered a revolutionary method for real-time assessment of changes in vascularization pattern in this tumors and it may open the possibility to address the use of anti-angiogenic therapy in order to improve the outcome of the treatment.