Pantoprazole before Endoscopy in Patients with Gastroduodenal Ulcer Bleeding: Does the duration of Infusion and Ulcer Location Influence the Effects?
Table 2
Outcomes with different durations of pantoprazole infusion compared to saline infusion for the total of 333 gastroduodenal ulcer bleeders.
Outcome (all ulcer bleeders)
Saline
Pantoprazole all
Pantoprazole 0–4 hrs
Pantoprazole >4 hrs
Pantoprazole >6 hrs
()
P value
()
P value
()
P value
()
P value
Number of pts. (%)
Number of pts. (%)
Number of pts. (%)
Number of pts. (%)
Endoscopic signs of bleeding
Active bleeding
23 (24.7%)
46 (19.2%)
0.26
32 (22.5%)
0.69
14 (14.3%)
0.07
12 (14.6%)
0.09
Nonbleeding visible vessel
18 (19.3%)
49 (20.4%)
0.83
29 (20.4%)
0.84
20 (20.4%)
0.86
19 (23.2%)
0.54
Clot
12 (12.9%)
52 (21.7%)
0.50
36 (25.3%)
0.02
16 (16.3%)
0.50
14 (27.1%)
0.44
Pigmented spot and clean base
40 (43.0%)
93 (38.8%)
0.48
45 (31.6%)
0.08
48 (48.9%)
0.41
37 (45.1%)
0.78
Urgent endoscopy
8 (8.6%)
19 (7.9%)
0.89
12 (8.4%)
0.91
7 (7.1%)
0.84
5 (6.1%)
0.64
Recurrent bleeding
13 (13.9%)
40 (16.7%)
0.55
21 (14.8%)
0.86
19 (19.4%)
0.32
17 (20.1%)
0.24
Emergency surgery
10 (10.7%)
21 (8.8%)
0.57
13 (9.2%)
0.68
8 (8.2%)
0.54
7 (8.5%)
0.62
Mortality
4 (4.3%)
15 (6.3%)
0.49
8 (5.6%)
0.65
7 (7.1%)
0.39
5 (6.1%)
0.59
P values were calculated for comparison between saline infusion group and pantoprazole infusion group patients with different durations of pantoprazole administration.
