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Gastroenterology Research and Practice
Volume 2012, Article ID 670418, 10 pages
Review Article

Effect of Gastrointestinal Surgical Manipulation on Metabolic Syndrome: A Focus on Metabolic Surgery

1Division of General Surgery, Department of Medico-Surgical Sciences and Biotechnology, Hospital ICOT, Sapienza University of Rome, via F. Faggiana 1668, 04100 Latina, Italy
2Division of General Surgery, Hospital of Civita Castellana, via Ferretti 169, 01033 Civita Castellana (VT), Italy

Received 12 July 2012; Accepted 6 September 2012

Academic Editor: Dan L. Dumitrascu

Copyright © 2012 Mario Rizzello et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Metabolic syndrome is strictly associated with morbid obesity and leads to an increased risk of cardiovascular diseases and related mortality. Bariatric surgery is considered an effective option for the management of these patients. We searched MEDLINE, Current Contents, and the Cochrane Library for papers published on bariatric surgery outcomes in English from 1 January 1990 to 20 July 2012. We reported the effect of gastrointestinal manipulation on metabolic syndrome after bariatric surgery. Bariatric surgery determines an important resolution rate of major obesity-related comorbidities. Roux-en-Y gastric bypass and biliopancreatic diversion appear to be more effective than adjustable gastric banding in terms of weight loss and comorbidities resolution. However, the results obtained in terms of weight loss and resolution of comorbidities after a “new bariatric procedure” (sleeve gastrectomy) encouraged and stimulated the diffusion of this operation.