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Gastroenterology Research and Practice
Volume 2012, Article ID 720865, 8 pages
http://dx.doi.org/10.1155/2012/720865
Research Article

TREM-1 Promotes Pancreatitis-Associated Intestinal Barrier Dysfunction

1Department of General Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China
2School of Clinical Medicine, Jiangsu University, Zhenjiang 212013, China

Received 6 October 2011; Revised 30 January 2012; Accepted 15 February 2012

Academic Editor: Marta Czesnikiewicz-Guzik

Copyright © 2012 Shengchun Dang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Severe acute pancreatitis (SAP) can cause intestinal barrier dysfunction (IBD), which significantly increases the disease severity and risk of mortality. We hypothesized that the innate immunity- and inflammatory-related protein-triggering receptor expressed on myeloid cells-1 (TREM-1) contributes to this complication of SAP. Thus, we investigated the effect of TREM-1 pathway modulation on a rat model of pancreatitis-associated IBD. In this study we sought to clarify the role of TREM-1 in the pathophysiology of intestinal barrier dysfunction in SAP. Specifically, we evaluated levels of serum TREM-1 and membrane-bound TREM-1 in the intestine and pancreas from an animal model of experimentally induced SAP. TREM-1 pathway blockade by LP17 treatment may suppress pancreatitis-associated IBD and ameliorate the damage to the intestinal mucosa barrier.