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Gastroenterology Research and Practice
Volume 2012 (2012), Article ID 879676, 9 pages
http://dx.doi.org/10.1155/2012/879676
Research Article

In Situ Absorption in Rat Intestinal Tract of Solid Dispersion of Annonaceous Acetogenins

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing 100193, China

Received 18 July 2011; Revised 23 October 2011; Accepted 11 November 2011

Academic Editor: D. Fan

Copyright © 2011 Yun-Jie Dang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Isolated from Annona squamosa L, Annonaceous acetogenins (ACGs) exhibit a broad range of biological properties yet absorbed badly due to the low solubility. Solid dispersion in polyethylene glycol 4000 (PEG 4000) has been developed to increase the solubility and oral absorption of ACGs. The formulation of ACGS-solid dispersion was optimized by a simplex lattice experiment design and carried out by a solvent-fusion method. We studied the absorption property of ACGs in rat’s intestine, which showed there was a good absorption and uptake percentages with solid dispersion. The study on uptake percentage in different regions of rat’s intestine attested that the duodenum had the best permeability, followed by jejunum, ileum, and colon in order with no significant differences. So the paper drew the conclusion that solid dispersion could improve the solubility and oral absorption of annonaceous acetogenins.