Expression Profiling of Proliferation and Apoptotic Markers along the Adenoma-Carcinoma Sequence in Familial Adenomatous Polyposis Patients

Table 2

Frequency of expression of beta-catenin, bcl-2, cyclin-D1, caspase-3, CD10, and Ki-67 in nonneoplastic mucosa, adenomas, and carcinomas.

	Beta-catenin	p53	Bcl-2	Cyclin-D1	Caspase-3	CD10	Ki-67 index
	(nuclear only)
Nonneoplastic mucosa	6/67 (9.0%)	0/71 (0%)	1/71 (1.4%)	3/66 (4.5%)	0/68 (0%)	4/66 (6.1%)	5%
Low grade adenomas	135/136 (99.3%)	9/126 (7.1%)	68/140 (48.6%)	111/126 (88.1%)	96/133 (72.2%)	1/136 (0.8%)	37%
High grade adenomas	12/12 (100%)	3/12 (25%)	6/12 (50%)	11/12 (91.7%)	6/12 (50%)	1/11 (9.1%)	32%
Invasive carcinomas	14/15 (93.3%)	12/17 (70.6%)	1/18 (5.6%)	13/16 (81.2%)	12/16 (75%)	6/15 (40%)	41%