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Gastroenterology Research and Practice
Volume 2013 (2013), Article ID 207129, 3 pages
Methodology Report

Therapeutic Endoscopic Ultrasonography: Intratumoral Injection for Pancreatic Adenocarcinoma

1Division of Surgical Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA
2Advantagene, Inc., Auburndale, MA 02466, USA
3Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH 43210-1267, USA

Received 22 February 2013; Accepted 7 March 2013

Academic Editor: Siyu Sun

Copyright © 2013 Lawrence A. Shirley et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Pancreatic adenocarcinoma is an aggressive disease that has poor outcomes despite maximal traditional therapies. Thus, treatment of this cancer demands innovative strategies to be used in addition to standing therapies in order to provide new avenues of care. Here, we describe the technique of using endoscopic ultrasound in order to directly inject both novel and conventional therapies into pancreatic tumors. We detail the rationale behind this strategy and the many benefits it provides. We then describe our technique in detail, including our experience injecting the AdV-tk adenoviral vector to create an in situ vaccine effect.