Functional Dyspepsia in Review: Pathophysiology and Challenges in the Diagnosis and Management due to Coexisting Gastroesophageal Reflux Disease and Irritable Bowel Syndrome

Table 1

Comparison of Rome II and Rome III.

	Rome II	Rome III
Duration of symptoms	12 weeks	12 weeks
Time period preceding diagnosis	12 months	6 months
Symptoms	Pain; Discomfort	Bothersome postprandial fullness; Early satiation; Burning; Pain
Location of symptoms	Centered in the upper abdomen	Epigastric
Need to rule out organic causes	Yes	Yes
Other exclusions	Not relieved by defecation; Not associated with change in stool frequency or form	None
	Ulcer like; Pain in the upper abdomen	Postprandial distress syndrome; Bothersome postprandial fullness after meals; Early satiation before finishing a regular meal
Subtypes; (feature/location of symptoms)	Dysmotility like; An unpleasant nonpainful sensation; centered in upper abdomen	Epigastric pain syndrome; Pain or burning at epigastrium; Pain of at least moderate severity; Pain is intermittent, not relieved by defecation; Pain not caused by gallbladder or sphincter of; Oddis dysfunction pain
	Unspecified; Symptoms do not fit in the above; categories