Preventive Effect of TU-100 on a Type-2 Model of Colitis in Mice: Possible Involvement of Enhancing Adrenomedullin in Intestinal Epithelial Cells
Figure 1
Effects of TU-100 on body weight and macroscopic colon lesions in OXN-induced colitis. Mice were presensitized with oxazolone (OXN, 1 mg/100 μL applied to skin), and then OXN (1 mg/100 μL) or vehicle, 50% ethanol, was instilled intrarectally (i.r.). TU-100 (900 mg/kg) was given orally to mice several hours, 1, 2, and 3 days after OXN instillation, and mice were sacrificed 4 days after OXN instillation. Body weight changes after OXN instillation (a), and macroscopic scores of colon lesions (b) are shown. Representative macroscopic images of each group are shown (c). Vehicle: 50% ethanol i.r. + water p.o., , OXN + water: OXN i.r. + water p.o., , OXN + TU-100: OXN i.r. + TU-100 p.o., , * versus colitis control by Student’s t-test.
