The Relation between Obesity and Survival after Surgical Resection of Hepatitis C Virus-Related Hepatocellular Carcinoma

Table 2

Univariate analysis contributing to OS and RFS for all cases (𝑛=233).

Variables	n	OS	RFS
		P value^a	P value^a
Age ≥ 70 (yes/no)	125/108	0.096	0.779
Gender (male/female)	159/74	0.070	0.445
HCC stages (I, II/III, and IV)	163/70	<0.001	<0.001
Maximum tumor size ≥ 3.5 cm (yes/no)	116/117	0.016	0.071
Tumor number (single/multiple)	162/71	0.005	<0.001
IFN therapy after surgery (yes/no)	16/217	0.039	0.019
Body mass index ≥ 25 kg/m^2 (yes/no)	60/173	0.818	0.124
Diabetes mellitus (yes/no)	64/169	0.311	0.994
ICGR 15 ≥ 13.5% (yes/no)	115/118	0.038	0.402
Total bilirubin ≥ 0.8 mg/dL (yes/no)	115/118	0.142	0.487
Serum albumin ≥ 3.8 g/dL (yes/no)	128/105	<0.001	0.088
AST ≥ 60 IU/L (yes/no)	110/123	0.090	0.042
ALT ≥ 50 IU/L (yes/no)	113/120	0.261	0.014
Platelets ≥ 12 × 10^4/mm^3 (yes/no)	128/105	0.065	0.679
Prothrombin time ≥ 87% (yes/no)	122/111	0.236	0.067
AFP ≥ 20 ng/mL (yes/no)	122/111	<0.001	0.010
DCP ≥ 100 mAU/mL (yes/no)	135/98	0.144	0.031
Total cholesterol ≥ 160 IU/L (yes/no)	109/124	0.476	0.575
Microscopic capsule (yes/no)	185/48	0.630	0.551
Microscopic capsule invasion (yes/no)	140/93	0.215	0.467
Microscopic vascular invasion (yes/no)	73/160	<0.001	<0.001
Microscopic surgical margin (yes/no)	30/203	0.642	0.112

OS: overall survival, RFS: recurrence-free survival, HCC: hepatocellular carcinoma, IFN: interferon, ICGR 15: indocyanine green retention at 15 min, AST: aspartate aminotransferase, ALT: alanine aminotransferase, AFP: alpha-fetoprotein, DCP: des-γ-carboxy prothrombin, and ^alog-rank test.