Gastroenterology Research and Practice / 2013 / Article / Tab 1

Clinical Study

International Consensus Diagnostic Criteria for Autoimmune Pancreatitis and Its Japanese Amendment Have Improved Diagnostic Ability over Existing Criteria

Table 1

Comparison of 6 major diagnostic criteria systems for AIP.

JPS-2006KoreanAsianHISORtICDCJPS-2011

(I) Imaging findingsMandatoryMandatoryMandatory Not mandatory Not mandatory Not mandatory
TypicalAtypicalTypicalIndeterminateTypicalIndeterminate

(a) Parenchymal imagingSwellingSwellingSwellingSwellingFocal mass/
calcification/
atrophy, etc.
Diffuse swellingSegmental/
focal swelling
Diffuse swellingSegmental/
focal swelling

(b) Ductal imagingERCP
irregular
narrowing
ERCP/MRCP
irregular
narrowing
ERCP
irregular
narrowing
Irregular narrowing Focal duct stricture Irregular narrowingERCP
Irregular narrowing

(II) Serology -Globulin/
IgG/IgG4/
autoantibodies
IgG/IgG4/
autoantibodies
IgG/IgG4/
autoantibodies
IgG4 IgG4 IgG4

(III) HistologyLPSPLPSP/IgG4-positive
plasma cells
LPSP/IgG4-positive
plasma cells
LPSP/IgG4-positive
plasma cells
LPSP/IgG4-positive
plasma cells
IDCP/GEL
LPSP/IgG4-positive
plasma cells

(IV) Other organ involvementNot includedIncludes
histological findings
Not included Includes
histological findings
Includes
histological findings/
clinical findingsΦ
Includes
histological findings/
clinical findings

(V) Response to steroidNot includedIncludes
pancreatic lesion/
extrapancreatic lesions
Optional
pancreatic lesion
Includes
pancreatic lesion/
extra-pancreatic lesions
Includes
pancreatic lesion/
extra-pancreatic lesions
Includes
pancreatic lesion/
extra-pancreatic lesions

DiagnosisI + II
I + III
I + II
I + III
I + IV
I + V
I + II
I + III
III 
I (typical) + II 
I (atypical) + II/IV + V
Shown in Table 3 Shown in Table 4

JPS-2011 requires evaluation by ERP in indeterminate imaging evidence.
Diagnosis of type 2 AIP requires histologically confirmed IDCP/GEL.
ΦFindings in type 1 AIP are sclerosing cholangitis, retroperitoneal fibrosis, Mikulicz disease, and renal disease. Finding in type 2 AIP is inflammatory bowel disease.
ERCP: endoscopic retrograde pancreatocholangiography; LPSP: lymphoplasmacytic sclerosing pancreatitis; IDCP: idiopathic duct-centric chronic pancreatitis; GEL: granulocytic epithelial lesion.

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