Combination Therapy of Ursodeoxycholic Acid and Corticosteroids for Primary Biliary Cirrhosis with Features of Autoimmune Hepatitis: A Meta-Analysis

Table 4

Descriptive results of the randomized trials.

Authors

Symptoms improved

Liver-biochemistry improved

Histology progression

Death

Death or liver transplantation

Adverse events

UDCA

COM.

UDCA

COM.

UDCA

COM.

UDCA

COM.

UDCA

COM.

UDCA

COM.

Chazouillères et al. [4]

2/5

3/6

2/5

6/6

3/5

0/2

1/5

0/6

1/5

0/6

1/5

2/6

Günsar et al. [21]

1/16

0/7

8/16

7/7

5/8

1/7

0/16

1/7

0/16

1/7

1/16

0/7

Chazouillères et al. [16]

3/11

0/6

4/11

6/6

4/8

0/4

NR

NR

0/11

1/6

NR

NR

Heurguè et al. [18]

1/6

1/4

3/6

3/4

3/6

1/4

NR

NR

0/6

0/4

NR

NR

Ozaslan et al. [20]

3/3

3/9

3/3

3/9

0/3

6/9

0/3

2/9

0/3

3/9

NR

NR

Tanaka et al. [17]

3/15

1/10

8/15

10/10

7/15

0/10

0/15

1/10

0/15

1/10

NR

NR

Zhu et al. [19]

0/11

0/8

6/11

8/8

3/3

0/3

NR

NR

0/11

0/8

2/11

1/8

UDCA: monotherapy with ursodeoxycholic acid; COM: combination therapy with UDCA and corticosteroids; NR: not reported.