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Gastroenterology Research and Practice
Volume 2014, Article ID 140587, 5 pages
Clinical Study

Clinicopathological and Prognostic Characteristics of Hepatoid Adenocarcinoma of the Stomach

1Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, China
2Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China
3Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China

Received 31 October 2013; Revised 27 December 2013; Accepted 1 January 2014; Published 11 February 2014

Academic Editor: D. Fan

Copyright © 2014 Jinlin Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The present study was undertaken to clarify the association of the clinicopathological features of hepatoid adenocarcinoma (HAC) in the stomach, a special kind of carcinoma that histologically resembled hepatocellular carcinoma (HCC) and is characterized by large amounts of α-fetoprotein (AFP) in serum, with the clinical prognosis. We collected the data of the clinicopathological features and the follow-up information from a total of 31 HACs from January 2005 to December 2012 in our hospital. High lymphatic (54.8%) and distant (25.8%) metastasis rates before surgery, large proportion of advanced HACs (71.0%) at admission, short median overall survival time (6 months), and low three-year survival rate (22.6%) suggested that HAC in the stomach was an aggressive disease, resulting in a poor prognosis. And pTNM stages, immunohistochemical staining of AFP, CEA, CK7, and CK20 had statistically relation with the survival as the independent risk factors, . Therefore, early and clear differentiation of HAC from cancerous or noncancerous conditions with AFP elevation and assessment of high risk patients by histopathology may improve the clinical prognosis.