Effectiveness and Safety of S-1-Based Therapy Compared with 5-Fluorouracil-Based Therapy for Advanced Colorectal Cancer: A Meta-Analysis

Table 2

Outcome of toxicity meta-analysis comparing S-1 versus 5-FU in advanced colorectal cancer.

Toxicity	Trials	SBT	FBT	Heterogeneity		OR (95% CI)	Model	value
				value	(%)
Grade 3-4 neutropenia	3	96/291	143/284	0.73	0	0.49 [0.35, 0.68]	Fixed	<0.01
Grade 3-4 leucopenia	10	79/734	100/726	0.28	18	0.75 [0.55, 1.04]	Fixed	0.08
Grade 3-4 anemia	9	41/712	31/705	0.40	3	1.33 [0.83, 2.15]	Fixed	0.24
Grade 3-4 thrombocytopenia	9	15/709	14/702	0.28	21	1.05 [0.51, 2.15]	Fixed	0.89
Grade 3-4 diarrhea	12	92/820	49/805	<0.1	64	1.25 [0.58, 2.69]	Random	0.57
Grade 3-4 nausea/vomit	10	15/739	38/732	0.56	0	0.41 [0.23, 0.72]	Fixed	<0.01
Grade 3-4 stomatitis	9	11/716	4/710	0.24	28	2.21 [0.83, 5.88]	Fixed	0.11
Treatment-related death	5	4/545	6/542	0.71	0	0.72 [0.24, 2.19]	Fixed	0.57

Notes: NA: not available; OR: odds ratio; CI: confidence interval; FBT: 5-fluorouracil-based therapy; SBT: S-1-based therapy.