Figure 5: Representation of laterally spreading tumors before and after the injection of a solution into the submucosal layer. (a) The almost flat muscularis mucosae of LST-NGs may lead to disperse the solution, elevating not only the lesion but also the surrounding mucosa. (b) In contrast, the wavy disposition of the muscularis mucosae of LST-Gs may facilitate to retain the solution beneath the lesion, elevating consequently the lesion and making propitious for EMR or ESD.