Gastroenterology Research and Practice / 2014 / Article / Tab 2

Research Article

The CIMP Phenotype in BRAF Mutant Serrated Polyps from a Prospective Colonoscopy Patient Cohort

Table 2

Correlation between polyp type, location, gender, size, BRAF V600E and KRAS mutations, CIMP, and methylation of MLH1, p16, and IGFBP7.

Clinical, pathological, and molecular featuresAll casesBRAF mutantKRAS mutantCIMP-HMLH1 methylationp16 methylationIGFBP7 methylationIGFBP7 and p16 methylation

All colorectal polyps21783 (38.25%)51 (23.5%)31 (14.29%)8 (3.69%)45 (20.74%)74 (34.1%)20 (9.22%)
Patient age (years, SD)
Gender
 Female 11550 (43.48%)26 (22.61%)19 (16.52%)4 (3.48%)28 (24.35%)49 (42.61%)16 (13.91%)
 Male10233 (32.35%)25 (24.51%)12 (11.76%)4 (3.92%)17 (16.67%)25 (24.51%)4 (3.92%)
Location
 Proximal11244 (39.29%)18 (16.07%)30 (26.79%)7 (6.25%)38 (33.93%)43 (38.39%)18 (16.07%)
 Distal10539 (37.14%)33 (31.43%)1 (0.95%)1 (0.95%)7 (6.67%)31 (29.52%)2 (1.9%)
Polyp type
 Serrated polyps15482 (53.25%)40 (25.97%)30 (19.48%)8 (5.19%)35 (22.73%)62 (40.26%)19 (12.34%)
  HP10948 (44.04%)35 (32.11%)9 (8.26%)1 (0.92%)16 (14.68%)35 (32.11%)4 (3.67%)
   GCHP5912 (20.34%)30 (50.85%)4 (6.78%)07 (11.86%)19 (32.2%)2 (3.39%)
   MVHP5036 (72%)5 (10%)5 (10%)1 (2%)9 (18%)16 (32%)2 (4%)
  TSA32 (66.67%)0 1 (33.33%)002 (66.67%)0
  MP74 (57.14%)2 (28.57%)2 (28.57%)02 (28.57%)3 (42.86%)1 (14.29%)
  SSA3528 (80%)3 (8.57%)18 (51.43%)7 (20%)17 (48.57%)22 (62.86%)14 (40%)
 Conventional adenomas631 (1.59%)11 (17.46%)1 (1.59%)010 (15.87%)12 (19.05%)1 (1.59%)
  TA521 (1.92%)4 (7.69%)1 (1.92%)06 (11.54%)10 (19.23%)1 (1.92%)
  TVA110 7 (63.64%)0 04 (36.36%)2 (18.18%)0
Size
 1–5 mm14450 (34.72%)37 (25.69%)13 (9.03%)3 (2.08%)22 (15.28%)44 (30.56%)8 (5.56%)
  >5 mm7333 (45.21%)14 (19.18%)18 (24.66%)5 (6.85%)23 (31.51%)30 (41.1%)12 (16.44%)
BRAF status
BRAF mutant83028 (33.73%)7 (8.43%)27 (32.53%)44 (53.01%)17 (20.48%)
BRAF wild13451 (38.06%)3 (2.24%)1 (0.75%)18 (13.43%)30 (22.39%)3 (2.24%)
KRAS status
KRAS mutant5100 07 (13.73%)8 (15.69%)1 (1.96%)
KRAS wild16683 (50%)31 (18.67%)8 (4.82%)38 (22.89%)66 (39.76%)19 (11.45%)