Aberrant MicroRNAs in Pancreatic Cancer: Researches and Clinical Implications

<table>Influences of miRNAs on the gemcitabine treatment in PDAC. miRNAs that are upregulated in PDAC inhibit gemcitabine-sensitive associated genes, such as PTEN, Bim, SHC1, BAX, and SMARCC1. Conversely, miRNAs that are downregulated in tumors inhibit gemcitabine-resistant associated genes, such as Pak-1, TUBB3, Notch1/2, Bcl-2, and FOG2.</table>

Gastroenterology Research and Practice

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Figure 1: Aberrant MicroRNAs in Pancreatic Cancer: Researches and Clinical Implications 