Review Article
Aberrant MicroRNAs in Pancreatic Cancer: Researches and Clinical Implications
Table 1
Important miRNAs deregulated in pancreatic ductal adenocarcinoma.
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D: biomarker for diagnosis, P: predictive value for prognosis, C: indicator for chemosensitivity, T: potential target for treatment. PTEN: phosphatase and tensin homolog, PDCD4: programed cell death 4, TPM1: tropomyosin 1, TIMP3: tissue inhibitor of metalloproteinases 3, CDKN1B (p27): cyclin-dependent kinase inhibitor 1B, PUMA: p53 upregulated modulator of apoptosis, TP53INP1: tumor protein 53-induced nuclear protein 1, SEL1L: Sel-1-like, HOXB8: Homeobox B8, ANXA1: annexin A1, HMGA2: high-mobility group AT-hook 2, SOCS6: cytokine-induced signaling 6, LATS2: large tumour suppressor homolog 2, Spry2: Sprouty2, HOXA1: Homeobox A1, FGFRL1: fibroblast growth factor receptor-like 1, HOXA9: Homeobox A9, CCNE1: cyclin E1, TCL1: T cell leukemia/lymphoma 1, DNMT3b: DNA methyltransferase 3b, Mitf: microphthalmia associated transcription factor, CCKBR: cholecystokinin-B receptor, BCL2: B cell lymphoma 2, MSLN: mesothelin, PBX-1: Pre-B-cell leukemia homeobox factor 1, VCP: valosin-containing protein, TRAF6: TNF receptor-associated factor 6, IRAK1: interleukin-1 receptor-associated kinase 1, Stat1: signal transducer and activator of transcription 1, Stat3: signal transducer and activator of transcription 3, PDK1: 3-phosphoinositide dependent protein kinase-1, MAPK: Mitogen-Activated Protein Kinase. |