Figure 2: Disease-free survival analysis stratified by CIMP status and treatment jointly. In CIMP negative tumors, adjuvant chemotherapy showed no effect on DFS with value =0.146 (a). Chemotherapy decreased DFS in CIMP+ tumors significantly with value =0.023 (b). CIMP status showed no effect on DFS in patients treated with surgery alone with value =0.462 (c). In patients receiving surgery plus adjuvant chemotherapy, CIMP positive patients had a significantly poor DFS than those negative with value <0.001 (d). DFS: disease-free survival, CIMP: CpG island methylator phenotype.