Predictors of Response to 24-Week Telaprevir-Based Triple Therapy for Treatment-Naïve Genotype 1b Chronic Hepatitis C Patients

Figure 1

According to the genetic variation in rs8099917, near the IL28B gene, a significantly higher proportion of patients with the TT genotype showed a sustained virological response (SVR) than did patients with the TG or GG genotype. In contrast, based on the amino acid substitutions in the core region (amino acid 70) and interferon sensitivity-determining region (ISDR), there was no significant association between the SVR rate and these substitutions, irrespective of the rs8099917 genotype. Furthermore, the SVR rate was 98.9% in patients with the rs8099917 TT genotype who achieved rapid virological response (RVR), whereas the SVR rate was 23.1% among patients with the TG or GG rs8099917 genotype who did not achieve RVR.