Genome-Wide and Gene-Specific Epigenomic Platforms for Hepatocellular Carcinoma Biomarker Development Trials

Figure 2

Heat map of the promoter-wide methylation data obtained by hybridizing to the Infinium array three hepatocellular carcinoma (HCC) samples and three nontumor liver samples from patients with no known liver disease. A dendrogram (tree graph) of the average beta values for three HCC samples and three nontumor samples was created with Spotfire (Somerville, MA). Unsupervised hierarchical clustering was performed with the unweighted average method using correlation as the similarity measure and ordering by average values. The color red was selected to represent high scores and the color green to represent low scores.