Determinants of Weight Loss prior to Diagnosis in Inflammatory Bowel Disease: A Retrospective Observational Study
Table 1
Disease characteristics of study population.
Ulcerative colitis
Crohn’s disease
All patients
Number of patients
257
237
494
Male : female (% female)
124 : 133 (51.8%)
117 : 120 (50.6%)
241 : 253 (51.2%)
Ethnic group
Caucasian
191 (74.3%)
198 (83.5%)
389 (78.7%)
Asian
41 (15.9%)
29 (12.2%)
70 (14.2%)
Afro-Caribbean
11 (4.3%)
4 (1.7%)
15 (3.0%)
Other
14 (5.4%)
6 (2.5%)
20 (4.0%)
Age at diagnosis (years)
Mean (st. error)
39.5 (1.05)
35.1 (1.09)
37.4 (0.76)
Range (median)
8–82 (35)
10–82 (30)
8–82 (33)
= 0.0041
Age group at diagnosis
A1 < 17
7 (2.7%)
17 (7.2%) = 0.034
24 (4.9%)
A2 17–40
145 (56.4%)
142 (59.9%)
287 (58.1%)
A3 > 40
105 (40.9%)
78 (32.9%)
183 (37.0%)
Smoking status
Nonsmoker
234 (91.1%)
182 (77.3%)
416 (84.2%)
Smoker
23 (8.9%)
55 (22.7%)
78 (15.8%)
< 0.0001
Appendectomy
Negative
167 (88.8%)
139 (78.5%)
306 (84.3%)
Positive
21 (11.1%)
38 (21.5%), = 0.0101
59 (15.7%)
Unknown
69
60
129
Family history of IBD
Positive
51 (19.8%)
45 (19.0%)
96 (19.4%)
Negative
206 (80.2%)
192 (81.0%)
398 (80.6%)
Family history of colorectal cancer
Positive
29 (12.4%)
21 (9.8%)
50 (11.2%)
Negative
205 (87.6%)
193 (90.2%)
398 (88.8%)
Unknown
23
23
46
History of IBD surgery
Positive
14 (8.0%)
88 (41.5%) < 0.0001
102 (26.4%)
Negative
161 (92.0%)
124 (58.5%)
285 (73.6%)
Unknown
82
25
107
Disease location
Ileal
N/A
37 (17.5%)
N/A
Ileocolonic
N/A
124 (58.8%)
N/A
Colonic
N/A
50 (23.7%)
N/A
Unknown
N/A
26
N/A
Disease behaviour
Inflammatory
N/A
139 (63.5%)
N/A
Stenotic
N/A
34 (15.6%)
N/A
Fistulating
N/A
46 (21.6%)
N/A
Unknown
N/A
18
N/A
All comparisons between UC and CD group were calculated with Fisher’s exact test, with the exception of mean age at diagnosis where nonpaired -test analysis was conducted. % calculated from patients with data only (i.e., unknown data excluded from % calculations).
