Determinants of Weight Loss prior to Diagnosis in Inflammatory Bowel Disease: A Retrospective Observational Study

Table 3

Regression analysis of %BMI change prior to diagnosis in CD/UC subgroups.

	Ulcerative colitis		Crohn’s disease
	Unadjusted univariate analysis	Multivariate analysis	Unadjusted univariate analysis	Multivariate analysis
Age at diagnosis; (per year)	−0.105	−0.14	−0.172	−0.161
	(−0.179–−0.031)	(−0.035–−0.0008)	(−0.258–−0.087)	(−0.25–−0.067)
	= 0.005	= 0.2150	= 0.0001	= 0.008
Montreal A1	9.066	1.445	6.018	2.841
	(1.285–16.847)	(−0.735–3.625)	(0.629–11.406)	(−2.951–8.633)
	= 0.0226	= 0.2150	= 0.0288	= 0.3348
Sex; (male versus female)	−0.827	−0.279	1.314	1.053
	(−3.331–1.677)	(−0.972–0.414)	(−1.616–4.244)	(−1.806–3.912)
	= 0.5160	= 0.4287	= 0.3780
Smoking at time of diagnosis; (versus nonsmoking)^*	−0.361	−0.429	2.778	3.426
	(−1.590–0.869)	(−1.670–0.811)	(−0.930–6486)	(−0.232–7.058)
	= 0.5641	= 0.4963	= 0.1413	= 0.0663
Ex-smoker; (versus nonsmokers)	−0.770	−0.717	0.135	2.324
	(−1.477–−0.062)	(−1.455–0.021)	(−3.308–3.578)	(−1.152–5.800)
	= 0.0331	= 0.0570	= 0.9384	= 0.1891
History of appendectomy; (versus none appendectomy)^**	0.364	0.503	−3.306	−4.170
	(−0.902–1.635)	(−0.785–1.791)	(−7.390–0.778)	(−8.219–−0.122)
	= 0.5738	= 0.4424	= 0.1121	= 0.0436
Ileal disease; (versus non ileal disease)	N/A	N/A	3.534	3.991
			(−0.457–7.525)	(0.068–7.913)
				= 0.0462

All variables are mutually adjusted for each other. ^*adjusted for ex-smokers. ^**adjusted for those where appendectomy data are missing.