Review Article

Risks of Misinterpretation in the Evaluation of the Effect of Fruit-Based Drinks in Postprandial Studies

Table 2

Studies with water as control.

ReferenceSubjects
(study design)
ControlTreatmentMetabolic markersInflammatory and redox markers

Ghanim et al., 2010 [20]30
(parallel)
HFM 900 kcal (51 g fat and CHO 81 g) + water
HFM + 300-kcal drink (75 g glucose)
HFM + orange juice (300 kcal)Glucose ↓
Insulin ↑
Glucose ↓
Insulin ↔
Oxidative burst ↓
TLR-2, TLR-4, LPS↓
Oxidative burst ↓
TLR-2, TLR-4, LPS↓

Hampton et al., 2010 [21]10
(crossover)
HFM 629 kcal (50% fat and CHO 33.3%) + waterHFM 629 kcal (50% fat and 33.3% CHO) + 122.5 mL Rabenhorst organic red grape juiceGlucose ↔
TG ↔

Panahi et al., 2013 [22]29
(crossover)
Pizza and water (fat 32 g, CHO 121.2 g, and sugars 21 g)
Pizza and cola (fat 30.5 g, CHO 166.8 g, and sugars 71.9 g)
Pizza and diet cola (fat 30.9 g, CHO 116.6 g, and sugars 20.6 g)
Pizza and orange juice (fat 31.7 g, CHO 178.9 g, and sugars 71.4 g)Glucose ↑
Glucose ↔
Glucose ↑

Stookey et al., 2012 [23]17
(crossover)
Breakfast with water 1527 KJ (fat 12 g and CHO 55 g)Breakfast with orange juice 2406 KJ (fat 12 g and CHO 106 g)Glucose ↔
Insulin ↑ (adolescents)
TG ↑ (adults)
TC ↔

CHO: carbohydrates; HFM: high fat meal; LPS: lipopolysaccharide; TC: total cholesterol; TG: triglycerides; TLR: Toll-like receptor.