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Gastroenterology Research and Practice
Volume 2014, Article ID 879595, 6 pages
Clinical Study

Lubiprostone Decreases the Small Bowel Transit Time by Capsule Endoscopy: An Exploratory, Randomised, Double-Blind, Placebo-Controlled 3-Way Crossover Study

1Hepatology and Gastroenterology, Yokohama City University Hospital, Kanagawa, Yokohama 236-0004, Japan
2Office of Postgraduate Medical Education, Yokohama City University Hospital, 3-9 Fukuura, Kanazawa-ku, Kanagawa, Yokohama 236-0004, Japan
3Division of Gastroenterology, Nippon Medical School, Tokyo 113-8603, Japan
4Department of General Medicine, Yokohama City University School of Medicine, Kanagawa, Yokohama 236-0004, Japan
5Department of Gastroenterology, Yokohama City University Hospital, Kanagawa, Yokohama 236-0004, Japan

Received 7 November 2014; Accepted 10 December 2014; Published 29 December 2014

Academic Editor: Antoni Castells

Copyright © 2014 Mizue Matsuura et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this study was to investigate the usefulness of lubiprostone for bowel preparation and as a propulsive agent in small bowel endoscopy. Six healthy male volunteers participated in this randomized, 3-way crossover study. The subjects received a 24 g tablet of lubiprostone 60 minutes prior to the capsule ingestion for capsule endoscopy (CE) and a placebo tablet 30 minutes before the capsule ingestion (L-P regimen), a placebo tablet 60 minutes prior to CE and a 24 g tablet of lubiprostone 30 minutes prior to CE (P-L regimen), or a placebo tablet 60 minutes prior to r CE and a placebo tablet again 30 minutes prior to CE (P-P regimen). The quality of the capsule endoscopic images and the amount of water in the small bowel were assessed on 5-point scale. The median SBTT was 178.5 (117–407) minutes in the P-P regimen, 122.5 (27–282) minutes in the L-P regimen, and 110.5 (11–331) minutes in the P-L regimen (). This study showed that the use of lubiprostone significantly decreased the SBTT. We also confirmed that lubiprostone was effective for inducing water secretion into the small bowel during CE.