Molecular Pathogenesis of MALT Lymphoma

Table 1

Genetic alterations in MALT lymphomas.

Name	Type	Affected gene	NF-κB activation	Subtype of MALT lymphoma mainly involved
t(1;14)(p22,q32)	Translocation	BCL10	Yes	Stomach, lung, and skin
t(11;18)(q21,q21)	Translocation	BIRC2, MALT1	Yes	Pulmonary, gastric
t(14;18)(q32,q21)	Translocation	MALT1	Yes	Ocular adnexa, orbit, skin, and salivary glands
t(3;14)(p14.1,q32)	Translocation	FOXP1	No
Trisomy 3	Trisomy	FOXP1; BCL6	No; No	Gastrointestinal
Trisomy 12	Trisomy	Unknown	No
Trisomy 18	Trisomy	Unknown	No
TNFAIP3	Deletion	TNFAIP3	Yes	Ocular adnexal, salivary gland, thyroid, and liver
PIM1	Mutation	PIM1	No	Gastric, extragastric
cMyc	Mutation	cMyc	No	Gastric, extragastric
P53	Mutation	P53	No
Myd88	Mutation	Myd88	Yes	Ocular adnexal
P16	Hypermethylation	P16	No
P57	Hypermethylation	P57	No
TNFAIP3	Hypermethylation	TNFAIP3	No	Ocular adnexal, salivary, and thyroidal glands

The two potentially affected genes.