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Gastroenterology Research and Practice
Volume 2015, Article ID 104794, 8 pages
http://dx.doi.org/10.1155/2015/104794
Clinical Study

Staging of Primary Abdominal Lymphomas: Comparison of Whole-Body MRI with Diffusion-Weighted Imaging and 18F-FDG-PET/CT

1Radiology Department, “Maggiore della Carità” University Hospital, University of Eastern Piedmont, Corso Mazzini 18, 28100 Novara, Italy
2Oncohaematology Department, Sant’Andrea Hospital, Corso Mario Abbiate 21, 13100 Vercelli, Italy
3Nuclear Medicine Department, “Maggiore della Carità” University Hospital, University of Eastern Piedmont, Corso Mazzini 18, 28100 Novara, Italy

Received 18 May 2015; Revised 22 August 2015; Accepted 23 August 2015

Academic Editor: Tatsuya Toyokawa

Copyright © 2015 Alessandro Stecco et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. The purpose of this study was to compare the accuracy of whole-body MRI with diffusion-weighted sequences (WB-DW-MRI) with that of 18F-FDG-PET/CT in the staging of patients with primary gastrointestinal lymphoma. Methods. This retrospective study involved 17 untreated patients with primary abdominal gastrointestinal lymphoma. All patients underwent 18F-FDG-PET/CT and WB-DW-MRI. Histopathology findings or at least 6 months of clinical and radiological follow-up was the gold standard. The Musshoff-modified Ann Arbor system was used for staging, and diagnostic accuracy was evaluated on a per-node basis. Results. WB-DW-MRI exhibited 100% sensitivity, 96.3% specificity, and 96.1% and 100% positive and negative predictive values (PPV and NPV), respectively. The sensitivity, specificity, and PPV and NPV of PET/CT were 95.9%, 100%, and 100% and 96.4%, respectively. There were no statistically significant differences between the two techniques . The weighted kappa agreement statistics with a 95% confidence interval were 0.97 (0.95–0.99) between the two MRI readers and 0.87 (0.82–0.92) between the two methods. Conclusions. WB-DW-MRI appears to have a comparable diagnostic value to 18F-FDG-PET/CT in staging patients with gastrointestinal lymphoma.