Molecular Features and Methylation Status in Early Onset (≤40 Years) Colorectal Cancer: A Population Based, Case-Control Study

Table 2

Molecular features of colorectal carcinomas in cases and in the control group.

Technical detail	Patients with onset ≤40 years		Control group >60 years, (%)
	Nonhereditary cases, (%)	Hereditary/suspect of hereditary cases, (%)
	MMR alterations
MSI and no expression; MMR proteins	0	7 (88)	4 (10)
Methylation
MLH1 or MSH2 promoter; hypermethylation	0	1 (13)	4 (10)
Somatic mutations
KRAS mutation	9 (36)	1 (13)	4 (10)
BRAF mutation	0	0	4 (10)
Germline mutations
MMR	0	5 (63)	0
APC	0	1 (13)	0
MUTYH	0	0	0