Gastroenterology Research and Practice / 2015 / Article / Tab 2

Research Article

Molecular Features and Methylation Status in Early Onset (≤40 Years) Colorectal Cancer: A Population Based, Case-Control Study

Table 2

Molecular features of colorectal carcinomas in cases and in the control group.

Technical detailPatients with onset ≤40 yearsControl group >60 years, (%)
Nonhereditary cases, (%)Hereditary/suspect of hereditary cases, (%)

MMR alterations
 MSI and no expression
  MMR proteins
07 (88)4 (10)
Methylation
MLH1 or MSH2 promoter
  hypermethylation
01 (13)4 (10)
Somatic mutations
KRAS mutation 9 (36)1 (13)4 (10)
BRAF mutation004 (10)
Germline mutations
MMR 05 (63)0
APC01 (13)0
MUTYH 000