Molecular Features and Methylation Status in Early Onset (≤40 Years) Colorectal Cancer: A Population Based, Case-Control Study

Table 3

Constitutional mutations in early onset colorectal cancer.

	Cases	Gene	Mutation
Lynch syndrome	5	MLH1 (3)	c.2246T>C; p.Leu749Pro
			c.1489dupC; p.Arg497ProfsX6
			c.1989G>T; p.Glu663Asp
		MSH2 (1)	c.881_882delTT; p.Phe294X
		EPCAM (1)	Del ex 8-9 and seq in 3′ to +3 kb
Familial Adenomatous Polyposis	1	APC	c.2771_2772insT; p. Arg924SerfsX16