Review Article
Role of TLR4 rs4986790A>G and rs4986791C>T Polymorphisms in the Risk of Inflammatory Bowel Disease
Table 2
Baseline characteristics of included studies.
| | First author | Year | Country | Ethnicity | Total | Sample size | Gender (M/F) | Age (years) | Genotyping methods | SNP | | Case | Control | Case | Control | Case | Control |
| | Mohammadia [15] | 2013 | Iran | Asians | 341 | 85 | 256 | 38/47 | 136/120 | 38 ± 16 | 37 ± 12 | PCR-RFLP | S1 & S2 | | Meenaa [28] | 2013 | India | Asians | 400 | 199 | 201 | 122/77 | 118/83 | 34.9 ± 11.6 | 36.4 ± 14.1 | PCR-RFLP | S1 & S2 | | Meenab [28] | 2013 | India | Asians | 247 | 46 | 201 | 25/21 | 118/83 | 32.58 ± 11.05 | 36.4 ± 14.1 | PCR-RFLP | S1 & S2 | | Sivarama [10] | 2012 | India | Asians | 315 | 139 | 176 | 187/128 | 40.97 ± 14.11 (18–80) | AS-PCR | S1 | |
Magalhäes Queiroza [29] | 2009 | Brazil | Caucasians | 583 | 42 | 541 | 6/36 | 409/132 | 38.93 ± 14.73 | 33.87 ± 9.96 | PCR-RFLP | S1 | |
Magalhäes Queirozb [29] | 2009 | Brazil | Caucasians | 584 | 43 | 541 | 20/23 | 409/132 | 40.88 ± 14.16 | 33.87 ± 9.96 | PCR-RFLP | S1 | | Rigolia [30] | 2008 | Italy | Caucasians | 148 | 45 | 103 | 27/18 | 68/35 | 43.2 ± 11.0 | 46.6 ± 9.8 | PCR-RFLP | S1 & S2 | | Rigolib [30] | 2008 | Italy | Caucasians | 236 | 133 | 103 | 70/63 | 68/35 | 43.5 ± 10.7 | 46.6 ± 9.8 | PCR-RFLP | S1 & S2 | | Lappalainena [31] | 2008 | Finland | Caucasians | 649 | 459 | 190 | NR | NR | PCR-RFLP | S1 & S2 | | Lappalainenb [31] | 2008 | Finland | Caucasians | 430 | 240 | 190 | NR | NR | PCR-RFLP | S1 & S2 | | Hongb [32] | 2007 | New Zealand | Caucasians | 370 | 182 | 188 | NR | NR | PCR-RFLP | S1 & S2 | | Browninga [33] | 2007 | New Zealand | Caucasians | 821 | 405 | 416 | 53/214 | 240/176 | NR | TaqMan assay | S1 & S2 | | Browningb [33] | 2007 | New Zealand | Caucasians | 805 | 389 | 416 | 64/250 | 240/176 | NR | TaqMan assay | S1 & S2 | | Baumgarta [16] | 2007 | Germany | Caucasians | 548 | 145 | 403 | 67/78 | NR | 31 ± 13.6 | NR | PCR-RFLP | S1 | | Baumgartb [16] | 2007 | Germany | Caucasians | 638 | 235 | 403 | 90/145 | NR | 26 ± 10.3 | NR | PCR-RFLP | S1 | | Oostenbruga [34] | 2005 | Netherlands | Caucasians | 516 | 217 | 299 | NR | NR | PCR-RFLP | S1 & S2 | | Oostenbrugb [34] | 2005 | Netherlands | Caucasians | 803 | 504 | 299 | NR | NR | PCR-RFLP | S1 & S2 | | Brandb [35] | 2005 | Germany | Caucasians | 403 | 204 | 199 | 96/108 | 99/100 | 37.8 ± 11.8 | 46.4 ± 15.3 | AS-PCR | S1 & S2 | | Töröka [36] | 2004 | Germany | Caucasians | 243 | 98 | 145 | 45/53 | 71/74 | 42.7 ± 13.3 | 44.6 ± 12.5 | PCR-RFLP | S1 & S2 | | Törökb [36] | 2004 | Germany | Caucasians | 247 | 102 | 145 | 37/65 | 71/74 | 40.9 ± 13.7 | 44.6 ± 12.5 | PCR-RFLP | S1 & S2 | | Franchimonta [37] | 2004 | Belgium | Caucasians | 302 | 163 | 139 | 85/78 | NR | 29.78 ± 12.8 | NR | PCR-RFLP | S1 | | Franchimontb [37] | 2004 | Belgium | Caucasians | 473 | 334 | 139 | 136/198 | NR | 26.6 ± 10.3 | NR | PCR-RFLP | S1 |
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M: male; F: female; SNP: single nucleotide polymorphism; aulcerative colitis; bCrohn’s disease; NR: not reported; PCR-RFLP: polymerase chain reaction-restriction fragment length polymorphism; AS-PCR: allele-specific polymerase chain reaction; S1: rs4986790A>G; S2: rs4986791C>T.
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