Role of TLR4  rs4986790A>G and rs4986791C>T Polymorphisms in the Risk of Inflammatory Bowel Disease

Table 3

Comparisons of genotype and allele frequencies between the case and the control groups.

Gene model		rs4986790A>G			rs4986791C>T
		OR	95% CI		OR	95% CI
M allele versus W allele (allele model)	Overall	1.268	1.124~1.431	<0.001	1.259	1.092~1.453	0.002
	Ethnicity
	Asians	1.246	0.945~1.642	0.119	1.608	1.080~2.395	0.019
	Caucasians	1.273	1.114~1.456	<0.001	1.215	1.042~1.415	0.013
	Disease
	CD	1.242	1.053~1.489	0.011	1.220	0.998~1.486	0.058
	UC	1.283	1.085~1.518	0.004	1.304	1.060~1.604	0.012
WM + MM versus WW (dominant model)	Overall	1.240	1.090~1.409	0.001	1.246	1.072~1.447	0.004
	Ethnicity
	Asians	1.099	0.812~1.489	0.540	1.517	1.000~2.303	0.050
	Caucasians	1.272	1.105~1.466	0.001	1.210	1.030~1.421	0.020
	Disease
	CD	1.247	1.039~1.497	0.018	1.219	0.991~1.499	0.061
	UC	1.233	1.030~1.475	0.023	1.276	1.026~1.588	0.028
MM versus WW (homozygous model)	Overall	2.438	1.413~4.204	0.001	1.933	0.971~3.850	0.061
WM versus MM (heterozygous model)	Overall	0.477	0.272~0.836	0.010	0.625	0.308~1.268	0.193
MM versus WW + WM (recessive model)	Overall	3.211	1.840~5.606	<0.001	1.891	0.950~3.764	0.070

OR: odds ratio; 95% CI: 95% confidential intervals; UC: ulcerative colitis; CD: Crohn’s disease.