Circulating Oxidized Low-Density Lipoproteins and Antibodies against Oxidized Low-Density Lipoproteins as Potential Biomarkers of Colorectal Cancer
Table 4
Relationships between serum levels of oxLDL and o-LAB and clinicopathological characteristics of patients with CRC (). Data are presented as median (interquartile range Q25–Q75).
Parameter
oxLDL (U/L)
value
o-LAB (U/L)
value
CEA (µg/L)
value
Age (years):
0.226
0.748
0.051
<70 ()
63.7 (53.2–88.1)
474.6 (260.8–1013.9)
1.2 (0.1–2.5)
≥70 ()
57.2 (47.6–79.2)
488 (300–1123.9)
2.7 (0.8–5.2)
Gender:
0.779
0.672
0.880
Male ()
64.4 (47.6–84.1)
493.8 (292.8–1030)
2.1 (0.7–3.7)
Female ()
54.5 (49.6–78.1)
450.8 (212.6–1054)
1.4 (0.8–5.2)
Histological grade:
0.984
0.617
0.083
G1 ()
68.7 (43.3–97.9)
199.4 (146.8–1223)
1.0 (0.1–2.5)
G2 ()
54.8 (48.4–82.6)
491.2 (310.4–1046)
1.7 (0.7–4.0)
G3 ()
66.1 (63.7–68.5)
602.6 (359.2–604.4)
5.2 (2.6–6.8)
Primary tumor:
0.247
0.027*
0.788
Right colon ()
68.5 (53.7–88.1)
774 (497–1148)1
1.5 (0.3–4.8)
Left colon ()
59.5 (44.0–84.1)
448 (204–1131)
2.6 (0.7–4.7)
Rectum ()
49.3 (46.6–69.1)
353 (286–451)1
1.7 (0.7–3.8)
TNM stage:
0.693
0.329
0.004*
I ()
88.2 (64.5–111.8)
227.4 (192.6–1203.5)
1.0 (0.1–1.3)5,6
II ()
54.8 (47.9–85.0)
579.1 (349.6–1133.5)
1.2 (0.7–2.4)
III ()
57.4 (50.1–84.1)
497.4 (280.4–939.6)
3.2 (1.0–7.1)5
IV ()
59.2 (49.0–68.5)
359.2 (244.3–450.8)
3.7 (2.6–5.3)6
T:
0.353
0.257
0.002*
1 + 2 ()
111.8 (71.8–116.9)2,3
1133.5 (212.6–1203.5)4
0.1 (0.1–0.8)7
3 ()
54.7 (47.6–84.1)2
407.6 (204.3–1013.9)
1.6 (0.8–2.7)
4 ()
54.6 (49.0–73.6)3
450.8 (349.6–687.2)4
2.8 (1.1–5.2)7
N:
0.472
0.258
0.005*
No ()
64.1 (48.4–85.0)
569.9 (310.4–1133.5)
1.3 (0.2–2.7)
Yes ()
54.7 (49.0–82.6)
407.6 (260.8–671.3)
3.7 (0.9–6.8)
M:
0.513
0.102
0.032*
No ()
60.1 (48.4–85.0)
530.6 (300.0–1128.7)
1.4 (0.6–3.5)
Yes ()
59.2 (49.0–68.5)
359.2 (244.3–450.8)
3.7 (2.6–5.3)
T: primary tumor progression; N: lymph node metastasis; M: distant metastasis; *statistically significant; 1 for right colon versus rectum; 2 for T1+2 versus T3; 3 for T1+2 versus T4; 4 for T1+2 versus T4; 5 for I versus III; 6 for I versus IV; 7 for T1+2 versus T4.
