Cumulative Small Effect Genetic Markers and the Risk of Colorectal Cancer in Poland, Estonia, Lithuania, and Latvia

Table 2

Genotype frequency analysis for each of the studied 6 risk markers, divided by country. ¹Conditional, ²Unconditional logistic regression. ^#After Bonferroni correction for multiple testing.

Marker	Risk allele	Estonia		Latvia		Lithuania		Poland
		Inheritance model	value^1; OR (95% CI)	Inheritance model	value^2; OR (95% CI)	Inheritance model	value^2; OR (95% CI)	Inheritance model	value^1; OR (95% CI)
rs3802842	C	Dominant	0.45; 1.18 (0.77–1.83)	Recessive	0.23; 2.17 (0.63–8.64)	Dominant	0.011 (0.022)^#; 1.98 (1.17–3.36)	Recessive	0.72; 1.07 (0.73–1.58)
rs4464148	C	Dominant	0.76; 1.08 (0.68–1.71)	Dominant	0.55; 1.26 (0.60–2.67)	Dominant	0.52; 1.20 (0.69–2.08)	Dominant	0.11; 1.19 (0.96–1.47)
rs4779584	T	Dominant	0.91; 1.03 (0.64–1.66)	Dominant	0.68; 1.14 (0.60–2.19)	Dominant	0.28; 1.33 (0.79–2.25)	Dominant	0.24; 1.13 (0.93–1.37)
rs4939827	T	Dominant	0.054; 1.74 (0.99–3.05)	Recessive	0.39; 1.45 (0.63–3.44)	Recessive	0.033 (0.066)^#; 2.10 (1.07–4.22)	Recessive	0.29; 1.14 (0.89–1.46)
rs6983267	G	Dominant	0.14; 1.46 (0.88–2.41)	Recessive	0.54; 1.24 (0.62–2.49)	Dominant	0.66; 1.15 (0.61–2.19)	Recessive	0.043 (0.086)^#; 1.23 (1.01–1.59)
rs10795668	A	Recessive	0.13; 1.42 (0.90–2.24)	Recessive	0.66; 1.15 (0.61–2.19)	Dominant	0.84; 1.06 (0.63–1.76)	Recessive	0.04 (0.08)^#; 1.23 (1.01–1.50)
all		Cumulative	= 0.0089; ( = 0.018)^#	Cumulative		Cumulative	= 0.0017; ( = 0.0034)^#	Cumulative	= 0.00038; ( = 0.0076)^#