Research Article

Helicobacter pylori Infection Is Associated with an Increased Risk of Hyperemesis Gravidarum: A Meta-Analysis

Table 2

Statistical analysis of studies on the rate of H. pylori infection in HG cases and non-HG controls.

First author, yearNumber of casesNumber of controlsNumber of cases with HP (+), (%)Number of controls with HP (+), (%)OR (95% CI)

Frigo, 1998 [16]10512995 (90.5)60 (46.5)10.93 (5.22, 22.85)
Perez-Perez, 1999 [18]42478 (19.1)12 (25.5)0.69 (0.25, 1.89)
Koćak, 1999 [17]9511687 (91.5)52 (44.8)13.38 (5.95, 30.13)
Hayakawa, 2000 [19]342918 (52.9)6 (20.6)4.31 (1.40, 13.25)
Sahin, 2000 [20]606037 (61.7)32 (53.3)1.41 (0.68, 2.91)
Reymunde, 2001 [21]454440 (89.0)3 (7.0)109.33 (24.49, 488.12)
Kazerooni, 2002 [24]545344 (81.5)29 (54.7)3.64 (1.52, 8.73)
Bagis, 2002 [23]201019 (95.0)5 (50.0)19.00 (1.79, 201.68)
Erdem, 2002 [22]473940 (85.1)25 (64.1)3.20 (1.14, 9.02)
Berker, 2003 [27]808056 (70.0)49 (61.2)1.48 (0.77, 2.85)
Jacobson, 2003 [26]5315319 (35.7)45 (29.7)1.34 (0.69, 2.60)
Salimi-Khayati, 2003 [25]545448 (88.9)22 (40.7)11.64 (4.25, 31.87)
Karaca, 2004 [31]569046 (82.1)58 (64.4)2.54 (1.13, 5.70)
Cevrioglu, 2004 [30]279723 (85.2)71 (73.2)2.11 (0.66, 6.67)
Xia, 2004 [29]7210064 (88.9)45 (45.0)9.78 (4.25, 22.51)
Jamal, 2004 [28]395526 (66.7)23 (41.8)2.78 (1.18, 6.54)
Lee, 2005 [32]404226 (65.0)28 (66.7)0.93 (0.37, 2.31)
Karadeniz, 2006 [34]312921 (67.7)23 (79.3)0.55 (0.17, 1.77)
Özcimen, 2006 [33]707035 (50.0)33 (47.1)1.12 (0.58, 2.18)
Tuncel, 2006 [35]508848 (96.0)73 (82.9)4.93 (1.08, 22.54)
Hatziveis, 2007 [38]258514 (56.0)41 (48.2)1.37 (0.56, 3.35)
Güney, 2007 [37]252020 (80.0)10 (50.0) 4.00 (1.07, 14.90)
Aytac, 2007 [36]525522 (42.3)22 (40.0)1.10 (0.51, 2.38)
Sandven, 2008 [39]244244105 (43.0)58 (23.8)2.42 (1.64, 3.57)
Mansour, 2009 [40]505042 (84.0)18 (36.0) 9.33 (3.60, 24.17)
Guven, 2011 [5]404032 (80.0)14 (35.0) 7.43 (2.70, 20.42)
Mansour, 2011 [4]808071 (88.8)24 (30.0) 18.41 (7.93, 42.74)
Bezircioğlu, 2011 [3]36368 (22.2)1 (2.8) 10.00 (1.18, 84.78)
Epstein, 2012 [41]235916 (69.6)38 (64.4)1.26 (0.45, 3.56)
Vikanes, 2013 [43]6210838 (61.3)67 (62.0)0.97 (0.51, 1.84)
Güngören, 2013 [42]905075 (83.3)30 (60.0)3.33 (1.51, 7.36)
Shaban, 2014 [6]505046 (92.0)28 (56.0) 9.04 (2.82, 28.95)

HG: hyperemesis gravidarum; OR: odds ratio; CI: confidence interval.