Immunohistochemical Expression of Dual-Specificity Protein Phosphatase 4 in Patients with Colorectal Adenocarcinoma
Table 2
Correlation between DUSP4 expression and clinicopathological factors in colorectal adenocarcinomas ( = 439).
Factors
DUSP4 expression
Negative (%) ( = 273)
Positive (%) ( = 166)
value
Age (years)
Mean ± SD
439
56.46 ± 13.30
59.51 ± 11.33
0.017†
0.114
Gender
Male
239
138 (57.7)
101 (42.3)
0.036‡
−0.100
Female
200
135 (67.5)
65 (32.5)
Tumor location
Colon
227
137 (60.4)
90 (39.6)
0.412‡
−0.039
Rectum
212
136 (64.2)
76 (35.8)
Tumor size
Mean ± SD
439
5.45 ± 1.92
6.05 ± 2.24
0.014†
0.117
Tumor type
Nonmucinous
418
255 (61.0)
163 (39.0)
0.023‡
−0.109
Mucinous
21
18 (85.7)
3 (14.3)
T category
Tis, T1, T2
46
35 (76.1)
11 (23.9)
0.040‡
0.098
T3, T4
393
238 (60.6)
155 (39.4)
N category
N0
192
123 (64.1)
69 (35.9)
0.618
0.025
N1
114
68 (59.6)
46 (40.4)
N2
133
82 (61.7)
51 (38.3)
AJCC stage
0, I, II
191
122 (63.9)
69 (36.1)
0.522‡
0.031
III, IV
248
151 (60.9)
97 (39.1)
Dukes stage
A, B
187
118 (63.1)
69 (36.9)
0.733‡
0.016
C, D
252
155 (61.5)
97 (38.5)
Differentiation
Well/Moderately
347
220 (63.4)
127 (36.6)
0.308‡
0.049
Poorly
92
53 (57.6)
39 (42.4)
Lymphatic invasion
Absent
186
120 (64.5)
66 (35.5)
0.388‡
0.041
Present
253
153 (60.5)
100 (39.5)
Vascular invasion
Absent
429
266 (62.0)
163 (38.0)
0.606‡
−0.025
Present
10
7 (70.0)
3 (30.0)
Mann-Whitney test; Chi-square test for independence; Chi-square test for linear trend. DUSP4: dual specificity protein phosphatase 4; SD: standard deviation; AJCC: American Joint Committee on Cancer; : Spearman’s rank correlation coefficient.