Gastroenterology Research and Practice

Research Article

Immunohistochemical Expression of Dual-Specificity Protein Phosphatase 4 in Patients with Colorectal Adenocarcinoma

Table 2

Correlation between DUSP4 expression and clinicopathological factors in colorectal adenocarcinomas ( = 439).


Factors		DUSP4 expression
Factors		Negative (%) ( = 273)	Positive (%) ( = 166)	value

Age (years)
Mean ± SD	439	56.46 ± 13.30	59.51 ± 11.33	0.017^†	0.114
Gender
Male	239	138 (57.7)	101 (42.3)	0.036^‡	−0.100
Female	200	135 (67.5)	65 (32.5)	0.036^‡	−0.100
Tumor location
Colon	227	137 (60.4)	90 (39.6)	0.412^‡	−0.039
Rectum	212	136 (64.2)	76 (35.8)	0.412^‡	−0.039
Tumor size
Mean ± SD	439	5.45 ± 1.92	6.05 ± 2.24	0.014^†	0.117
Tumor type
Nonmucinous	418	255 (61.0)	163 (39.0)	0.023^‡	−0.109
Mucinous	21	18 (85.7)	3 (14.3)	0.023^‡	−0.109
T category
Tis, T1, T2	46	35 (76.1)	11 (23.9)	0.040^‡	0.098
T3, T4	393	238 (60.6)	155 (39.4)	0.040^‡	0.098
N category
N0	192	123 (64.1)	69 (35.9)	0.618	0.025
N1	114	68 (59.6)	46 (40.4)
N2	133	82 (61.7)	51 (38.3)
AJCC stage
0, I, II	191	122 (63.9)	69 (36.1)	0.522^‡	0.031
III, IV	248	151 (60.9)	97 (39.1)	0.522^‡	0.031
Dukes stage
A, B	187	118 (63.1)	69 (36.9)	0.733^‡	0.016
C, D	252	155 (61.5)	97 (38.5)	0.733^‡	0.016
Differentiation
Well/Moderately	347	220 (63.4)	127 (36.6)	0.308^‡	0.049
Poorly	92	53 (57.6)	39 (42.4)	0.308^‡	0.049
Lymphatic invasion
Absent	186	120 (64.5)	66 (35.5)	0.388^‡	0.041
Present	253	153 (60.5)	100 (39.5)	0.388^‡	0.041
Vascular invasion
Absent	429	266 (62.0)	163 (38.0)	0.606^‡	−0.025
Present	10	7 (70.0)	3 (30.0)	0.606^‡	−0.025

Mann-Whitney test; Chi-square test for independence; Chi-square test for linear trend.
DUSP4: dual specificity protein phosphatase 4; SD: standard deviation; AJCC: American Joint Committee on Cancer; : Spearman’s rank correlation coefficient.