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Gastroenterology Research and Practice
Volume 2015, Article ID 287348, 6 pages
Review Article

Role of Gut Barrier Function in the Pathogenesis of Nonalcoholic Fatty Liver Disease

Tianjin Medical University General Hospital, Tianjin 300052, China

Received 10 February 2015; Accepted 28 March 2015

Academic Editor: Haruhiko Sugimura

Copyright © 2015 Xin Dai and Bangmao Wang. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Nonalcoholic fatty liver disease (NAFLD) is one of the most common forms of chronic liver disease, and its incidence is increasing year by year. Many efforts have been made to investigate the pathogenesis of this disease. Since 1998 when Marshall proposed the conception of “gut-liver axis,” more and more researchers have paid close attention to the role of gut barrier function in the pathogenesis of NAFLD. The four aspects of gut barrier function, including physical, chemical, biological, and immunological barriers, are interrelated closely and related to NAFLD. In this paper, we present a summary of research findings on the relationship between gut barrier dysfunction and the development of NAFLD, aiming at illustrating the role of gut barrier function in the pathogenesis of this disease.