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Gastroenterology Research and Practice
Volume 2015 (2015), Article ID 305258, 9 pages
http://dx.doi.org/10.1155/2015/305258
Research Article

CNP-pGC-cGMP-PDE3-cAMP Signal Pathway Upregulated in Gastric Smooth Muscle of Diabetic Rats

1Department of Physiology, Yanbian University School of Medicine, 977 Gongyuan Road, Yanji, Jilin 133002, China
2Department of Physiology, Shanghai Jiaotong University School of Medicine, 800 Dongchuan Road, 328 Wenxuan Medical Building, Shanghai 200240, China

Received 13 August 2014; Accepted 1 October 2014

Academic Editor: Jae Yeoul Jun

Copyright © 2015 Ying-Lan Cai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. B. Zhao, J. B. Frøkjær, A. M. Drewes, and N. Ejskjaer, “Upper gastrointestinal sensory-motor dysfunction in diabetes mellitus,” World Journal of Gastroenterology, vol. 12, no. 18, pp. 2846–2857, 2006. View at Google Scholar · View at Scopus
  2. N. J. Talley, L. Young, P. Bytzer et al., “Impact of chronic gastrointestinal symptoms in diabetes mellitus on health-related quality of life,” The American Journal of Gastroenterology, vol. 96, no. 1, pp. 71–76, 2001. View at Publisher · View at Google Scholar · View at Scopus
  3. Y. Komatsu, K. Nakao, S.-I. Suga et al., “C-type natriuretic peptide (CNP) in rats and humans,” Endocrinology, vol. 129, no. 2, pp. 1104–1106, 1991. View at Publisher · View at Google Scholar · View at Scopus
  4. W. R. Gower Jr., K. F. Salhab, W. L. Foulis et al., “Regulation of atrial natriuretic peptide gene expression in gastric antrum by fasting,” American Journal of Physiology: Regulatory Integrative and Comparative Physiology, vol. 278, no. 3, pp. R770–R780, 2000. View at Google Scholar · View at Scopus
  5. H.-S. Guo, X. Cui, Y.-G. Cui et al., “Inhibitory effect of C-type natriuretic peptide on spontaneous contraction in gastric antral circular smooth muscle of rat,” Acta Pharmacologica Sinica, vol. 24, no. 10, pp. 1021–1026, 2003. View at Google Scholar · View at Scopus
  6. H.-S. Guo, Z. Jin, Z.-Y. Jin et al., “Comparative study in the effect of C-type natriuretic peptide on gastric motility in various animals,” World Journal of Gastroenterology, vol. 9, no. 3, pp. 547–552, 2003. View at Google Scholar · View at Scopus
  7. M. S. Barnette, F. C. Barone, M. Grouse, T. J. Torphy, and H. S. Ormsbee III, “Smooth muscle cyclic GMP (cGMP) is elevated by activating enteric neurones in the lower esophageal sphincter (LES) muscle of three specie,” Gastroenterology, vol. 95, article 85, 1988. View at Google Scholar
  8. M. Barnette, T. J. Torphy, M. Grous, C. Fine, and H. S. Ormsbee III, “Cyclic GMP: a potential mediator of neurally- and drug-induced relaxation of opossum lower esophageal sphincter,” Journal of Pharmacology and Experimental Therapeutics, vol. 249, no. 2, pp. 524–528, 1989. View at Google Scholar · View at Scopus
  9. M. S. Barnette, C. D. Manning, W. J. Price, and F. C. Barone, “Initial biochemical and functional characterization of cyclic nucleotide phosphodiesterase isozymes in canine colonic smooth muscle,” Journal of Pharmacology and Experimental Therapeutics, vol. 264, no. 2, pp. 801–812, 1993. View at Google Scholar · View at Scopus
  10. A. F. Joslyn, M. S. Barnette, M. Grous et al., “Cyclic nucleotides increase during neuronally induced relaxation of sphincteric and nonsphincteric gastrointestinal smooth muscle,” Journal of Gastrointestinal Motility, vol. 2, no. 1, pp. 65–72, 1990. View at Google Scholar · View at Scopus
  11. A. F. Joslyn, M. Fudge, M. S. Barnette, C. D. Manning, F. C. Barone, and H. S. Ormsbee III, “Relaxation of guinea-pig proximal colon (PC) and taenia coli (TC) smooth muscle is regulated by cyclic nucleotide (CN) content,” Gastroenterology, vol. 94, article A212, 1988. View at Google Scholar
  12. R. C. Small, J. P. Boyle, K. R. F. Elliott, R. W. Foster, and A. J. Watt, “Inhibitory effects of AH 21–132 in guinea-pig isolated ileum and taenia caeci,” British Journal of Pharmacology, vol. 97, no. 4, pp. 1174–1181, 1989. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Grous, A. F. Joslyn, W. Thompson, and M. S. Barnette, “Change in intracellular cyclic nucleotide content accompanies relaxation of the isolated canine internal anal sphincter,” Journal of Gastrointestinal Motility, vol. 3, no. 1, pp. 46–52, 1991. View at Google Scholar · View at Scopus
  14. J. A. Beavo and D. H. Reifsnyder, “Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors,” Trends in Pharmacological Sciences, vol. 11, no. 4, pp. 150–155, 1990. View at Publisher · View at Google Scholar · View at Scopus
  15. C. D. Nicholson, R. A. J. Challiss, and M. Shahid, “Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes,” Trends in Pharmacological Sciences, vol. 12, no. 1, pp. 19–27, 1991. View at Publisher · View at Google Scholar · View at Scopus
  16. W. J. Thompson, “Cyclic nucleotide phosphodiesterases: pharmacology, biochemistry and function,” Pharmacology and Therapeutics, vol. 51, no. 1, pp. 13–33, 1991. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Zaccolo and M. A. Movsesian, “cAMP and cGMP signaling cross-talk: role of phosphodiesterases and implications for cardiac pathophysiology,” Circulation Research, vol. 100, no. 11, pp. 1569–1578, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. Y.-L. Cai, D.-Y. Xu, X.-L. Li, Z.-X. Qiu, Z. Jin, and W.-X. Xu, “C-type natriuretic-peptide-potentiated relaxation response of gastric smooth muscle in streptozotocin-induced diabetic rats,” World Journal of Gastroenterology, vol. 15, no. 17, pp. 2125–2131, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. D. Y. Xu, L. Liu, Y. L. Cai et al., “Natriuretic peptide-dependent cGMP signal pathway potentiated the relaxation of gastric smooth muscle in streptozotocin-induced diabetic rats,” Digestive Diseases and Sciences, vol. 55, no. 3, pp. 589–595, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. Y.-L. Cai, Q. Sun, X. Huang et al., “cGMP–PDE3–cAMP signal pathway involved in the inhibitory effect of CNP on gastric motility in rat,” Regulatory Peptides, vol. 180, no. 1, pp. 43–49, 2013. View at Publisher · View at Google Scholar · View at Scopus
  21. G. A. Robison, R. W. Butcher, and E. W. Sutherland, “Cyclic AMP and hormone action,” in Cyclic AMP, pp. 17–47, Academic press, New York, NY, USA, 1971. View at Google Scholar
  22. J. P. Gray, G. I. Drummond, D. W. T. Luk, J. G. Hardman, and E. W. Sutherland, “Enzymes of cyclic nucleotide metabolism in invertebrate and vertebrate sperm,” Archives of Biochemistry and Biophysics, vol. 172, no. 1, pp. 20–30, 1976. View at Publisher · View at Google Scholar · View at Scopus
  23. J. F. Wen, X. Cui, J. Y. Jin et al., “High and Low Gain Switches for Regulation of cAMP Efflux Concentration: distinct Roles for Particulate GC- and Soluble GC-cGMP-PDE3 Signaling in Rabbit Atria,” Circulation Research, vol. 94, no. 7, pp. 936–943, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. E. Qvigstad, L. R. Moltzau, J. M. Aronsen et al., “Natriuretic peptides increase β1-adrenoceptor signalling in failing hearts through phosphodiesterase 3 inhibition,” Cardiovascular Research, vol. 85, no. 4, pp. 763–772, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. Y.-S. Wu, H.-L. Lu, X. Huang et al., “Diabetes-induced loss of gastric ICC accompanied by up-regulation of natriuretic peptide signaling pathways in STZ-induced diabetic mice,” Peptides, vol. 40, pp. 104–111, 2013. View at Publisher · View at Google Scholar · View at Scopus