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Gastroenterology Research and Practice
Volume 2015, Article ID 309156, 5 pages
http://dx.doi.org/10.1155/2015/309156
Clinical Study

The Genetic Predisposition and Its Impact on the Diabetes Mellitus Development in Patients with Alcoholic Chronic Pancreatitis

1Department of Gastroenterology with Endoscopic Units, Medical University, Jaczewski Street 8, 20-954 Lublin, Poland
2Department of Forensic Medicine, Medical University, Ceramiczna Street 1, 20-150 Lublin, Poland
3Department of Medical Chemistry, Medical University, Chodźki Street 4a, 20-093 Lublin, Poland

Received 2 January 2015; Accepted 4 March 2015

Academic Editor: Paul Enck

Copyright © 2015 Agnieszka Madro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The most common cause of chronic pancreatitis (CP) is alcohol abuse. The aim of the present study was to identify patients with genetic predisposition to CP abusing alcohol. The question posed was whether CP manifests at a younger age and diabetes mellitus develops earlier in individuals with genetic predisposition. The study encompassed 79 patients with alcoholic chronic pancreatitis (ACP) and control group (100 persons). The following mutations were determined: R122H and N29I of PRSS1 and N34S of SPINK1 as well as E366K and E288V of SERPINA 1. No R122H and N291 mutations were observed in the group of ACP patients and in controls. Moreover, there was no E288V mutation. In 79 ACP patients, six SPINK 1 (N34S/wt) mutations were observed. In the control group, one heterozygous SPINK 1N34S gene mutation was found (). Two PiZ mutations were identified in patients with ACP and one analogical mutation in controls. Amongst patients with ACP as well as SPINK1 and PiZ mutations, the onset of disease was observed earlier and developed earlier. The prevalence of SPINK1 mutation is higher in patients with ACP than in healthy populations. This mutation together with the effects of alcohol accelerates the development of ACP and of diabetes mellitus.