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Gastroenterology Research and Practice
Volume 2015, Article ID 314158, 8 pages
Review Article

Gastric Collision Tumors: An Insight into Their Origin and Clinical Significance

11st Department of Surgery, University of Athens, Laiko Hospital, 17 Agiou Thoma Street, 11527 Athens, Greece
2The Institute of Cancer Research and the Royal Marsden Hospital, 15 Cotswold Road, London SM2 5NG, UK

Received 19 November 2014; Revised 13 January 2015; Accepted 14 January 2015

Academic Editor: Paolo Gionchetti

Copyright © 2015 Adamantios Michalinos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Collision tumors are rare neoplasms displaying two distinct cell populations developing in juxtaposition to one another without areas of intermingling. They are rare entities with only 63 cases described in English literature. Tumors encountered are gastric adenocarcinomas colliding with lymphomas, gastrointestinal stromal tumors, squamous cell carcinomas, and neuroendocrine tumors. Their cell origin is obsolete by the time of diagnosis. Different tumorigenesis theories have been suggested to explain their behavior, yet none has managed to provide satisfactory explanation for all cases. Clinically they are indistinguishable from the dominant tumor. Lack of data does not allow detailed assessment of their behavior yet they seem aggressive neoplasms with dismal prognosis. The majority of cases have been diagnosed postoperatively during histologic examination of specimens. There are no guidelines or concrete evidence to support best way of adjuvant or other types of treatment. However, these rare neoplasms might help in unlocking secrets of cancer behavior including tumorigenesis, differentiation, and adhesion and thus clinicians should be aware of their existence.