Gastroenterology Research and Practice / 2015 / Article / Tab 4

Clinical Study

Outcomes and Risk Factors Associated with Clostridium difficile Diarrhea in Hospitalized Adult Patients

Table 4

Factors associated with poor prognosis among 75 hospitalized adult patients with Clostridium difficile colitis according to univariate logistic regression.

VariablePoor prognosis
group ()
Good prognosis group ()OR (95% CI)P value

Age, years, median (IQR)59.0 (39.5–76.0)55.0 (35.0–67.0)1.008 (0.98–1.03)0.46
Charlson comorbidity index, median (IQR)3.0 (2.0–5.0) 2.0 (1.0–5.0)1.68 (0.66–4.24)0.22
HIV infection3 (9.3)2 (4.6)2.12 (0.33–13.50)0.42
Proton pump inhibitors use25 (78.1)28 (65.1)1.91 (0.67–5.44)0.22
Enteral tube feeding19 (59.3)11 (25.5)4.25 (1.59–11.36)0.004
Cytotoxic chemotherapy in the previous 6 weeks6 (18.7)13 (30.2)0.53 (0.17–1.60)0.26
Hospitalization in the previous 6 months19 (59.3)30 (69.7)0.63 (0.24–1.65)0.35
Gastrointestinal surgery in the previous 30 days5 (15.6)2 (4.6)3.79 (0.68–20.99)0.12
Length of antibiotic treatment, days, median (IQR)10.0 (7.0–15.0)10.0 (7.0–14.0)1.07 (0.96–1.19)0.19
Fever9 (28.1)8 (18.6)1.71 (0.57–5.08)0.33
Lethargy2 (6.2)2 (4.6)1.36 (0.18–10.25)0.76
Dehydration4 (12.5)5 (11.6)1.08 (0.26–4.41)0.90
Tachycardia3 (9.3)2 (4.6)2.12 (0.33–13.50)0.42
Abdominal pain8 (25.0)18 (41.8)0.46 (0.16–1.26)0.13
Abdominal distension13 (40.6)11 (25.5)1.99 (0.74–5.32)0.17
Anorexia2 (6.2)4 (9.3)0.65 (0.11–3.78)0.63
Nausea2 (6.2)5 (11.6)0.50 (0.09–2.79)0.43
Hematochezia1 (3.1)5 (11.6)0.24 (0.02–2.20)0.21
Leukocytosis or leukopenia13 (40.6)25 (58.1)0.49 (0.19–1.24)0.13
Initial serum creatinine, mg/dL, median (IQR)1.1 (0.7–3.05)0.8 (0.6–1.3)1.27 (0.93–1.72)0.12
Initial plasma CPR, mg/L, median (IQR)63.0 (33.5–174.0)84.5 (47.0–157.0)0.99 (0.99–1.00)0.75
Initial plasma albumin, g/dL, median (IQR)2.7 (2.3–3.3)3.2 (2.7–3.6)0.46 (0.21–1.03)0.06
Initial serum lactate, mmol/L, median (IQR)1.1 (0.85–2.2)0.75 (0.6–0.95)0.40 (0.59–1.81)0.10

Data presented as (%) unless otherwise indicated. CPR: C-reactive protein; OR: odds ratio; CI: confidence interval; IQR: interquartile range (P25–P75).
Composite endpoint that includes in-hospital mortality, ICU admission, and treatment failure.

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